Cryotherapy is also beneficial in addressing depression arising from suffering chronic pain. As cryotherapy is recognised as having a significant impact on reducing pain and promoting muscle healing and increasing range of motion it has the flow on effect of the patient feeling better both physically and mentally.

It has been shown that WBC promotes physiological hormonal responses such as the release of adrenaline, noradrenaline, and endorphins known to have a positive effect on individuals experiencing mood disorders such as anxiety and depression.