It has been shown that whole of body cryotherapy (WBC) promotes physiological hormonal responses such as the release of adrenaline, noradrenaline, and endorphins all known to have a positive effect on individuals experiencing mood disorders such as anxiety and depression.

Studies undertaken indicate some patients received a significant reduction in the severity of symptoms when using WBC, either as a stand-alone treatment or as an adjunct to current therapies. Another study has indicated a reduction of 80 percent of suicidal thoughts after a cryotherapy treatment program., in some patients.